Dr. Jarek Król, Postdoctoral Scientist
…Publications
Articles
2008
J. Król, Mazur A., M. Marczak, A. Skorupska 2008, Application of physical and genetic map of Rhizobium leguminosarum bv. trifolii TA1 to comparison of three closely related rhizobial genomes. MGG 279, 2, 107-121.
Olender,A., Król,J.E., Ruminski,W., Zawadzki,A. and Niemcewicz,M. 2008. Corynebacterium diphtheriae (tox-) - participation in two cases of atypical infection. FEMSIM - submitted
2007
J. Król, Mazur A., M. Marczak, A. Skorupska 2007, Syntenic arrangements of the surface polysaccharide biosynthesis genes in Rhizobium leguminosarum. Genomics 2007 89, 2, 237-247.
2006
Skorupska A, Janczarek M, Marczak M, Mazur A, J. Król 2006, Rhizobial exopolysaccharides: genetic control and symbiotic functions. Microb Cell Fact. 16, 5-17.
M. Marczak, Mazur A., J. Król, Gruszecki W.I., A. Skorupska 2006 Lipoprotein PssN of Rhizobium leguminosarum bv. trifolii: subcellular localization and possible involvement in exopolysaccharide export. J. Bacteriol. 188, 6943-6952
Chudnicka A., J. Król, Koziol-Montewka M., Bogut A. 2006 Propionibacterium – a pathogen, an opportunistic microorganism. Polish J. Environ. Stud. 15, 2b, 1038-1041
Skorupski P., J. Król, Starega J., Adamiak A., Jankiewicz K., Rechberger T. 2006. An alpha-1 chain of type I collagen Sp1-binding site polymorphism in women suffering from stress urinary incontinence. Am J Obstet Gynecol.194, 346-350
2005
Mazur A., M. Marczak, J. Król, A. Skorupska 2005. Topological and transcriptional analysis of pssL gene product: a putative Wzx-like exopolysaccharide translocase in Rhizobium leguminosarum bv. trifoliiTA1. Arch. Microbiol. 184, 1-10.
2004
Wielbo J., Mazur A., J. Król, Marczak M., Kutkowska J. and Skorupska A. 2004. Complexity of phenotypes and symbiotic behaviour of Rhizobium leguminosarum biovar trifolii exopolysaccharide mutants. Arch. Microbiol. 182, 331 – 336.
2003
Mazur A., J. Król, M. Marczak, A. Skorupska 2003. Membrane topology of PssT, the transmembrane protein component of the type I exopolysaccharide transport system in Rhizobium leguminosarum bv. trifolii strain TA1. J. Bacteriol. 185, 2503-2511.
2002
Mazur A., J. Król, J. Wielbo, T. Urbanik-Sypniewska, A. Skorupska 2002. Rhizobium leguminosarum bv. trifolii PssP protein is required for exopolysaccharide biosynthesis and polymerization. Mol. Plant Microbe Interact. 15, 388-397.
2001
Mazur A., J. Król, A. Skorupska 2001. Rhizobium leguminosarum bv. trifolii pssNOP genes encoding proteins involved in polymerization and translocation of exopolysaccharide. DNA Sequence 12, 1-12.
Janczarek M., J. Król, J. Kutkowska, A. Mazur, J. Wielbo, W. Borucki, J. Kopcinska, B. Lotocka, T. Urbanik-Sypniewska, A. Skorupska 2001. Mutation in the pssB-pssA intergenic region of Rhizobium leguminosarum bv. trifolii affects the surface polysaccharides synthesis and nitrogen fixation ability, J Plant Physiol. 158, 1565-1574.
2000
Skorupska A., Janczarek M., J. Król, Marek-Kozaczuk M., Mazur A., Wielbo J. 2000. Biotic stress during symbiosis in leguminous plants. In: Stress in biological and medical research. Lublin, 2000. str. 9-15.
Lorkiewicz Z., Lisova N., Skorupska A., Russa, R.,Glowacka M., Kowalczuk E., Urbanik-Sypniewska T., Choma A., Malek W., Galan M., J. Król, Kalabun J., Szyprowska S., Marek-Kozaczuk M., Turska A., Wdowiak S., Janczarek M., Dolecka J., Mazur A., Melke A. 2000. The Rhizobium – Plant symbiosis. W: Bull. Polish Academy of Science, Lublin. pp. 51-60.
1999
Janczarek M., Mazur A., Wielbo J., J. Król, Skorupska A. 1999. Rhizobial exopolysaccharides: structures, biosynthesis and function in symbiosis. Postepy Mikrobiologii. 38, 217-244.
Janczarek M., J. Król, A. Skorupska 1999. The pssB gene productsof Rhizobium leguminosarum bv trifolii is homologous to a family of inositol monophosphatase. FEMS Microbiol. Lett. 173, 319-325.
1998
J. Król, J. Wielbo., A. Mazur., J. Kopcinska, B. Lotocka, W. Golinowski, A. Skorupska, 1998. Molecular characterization of pssCDE genes of Rhizobium leguminosarum bv. trifolii strain TA1: pssD mutant is affected in exopolysaccharide synthesis and endocytosis of bacteria. Mol. Plant-Microbe Interact. 11. 1142-1148
Mazur A., J. Wielbo, J. Król, J. Kopcinska, B. Lotocka, W. Golinowski, A. Skorupska, 1998. Molecular characterization and symbiotic importance of prsD gene of Rhizobium leguminosarum bv. trifolii TA1. Acta Bioch. Polon. 45, 1067-1073.
1997
J. Król, A. Skorupska, 1997. Identification of the genes in Rhizobium leguminosarum bv. trifolii whose products are homologues to a family of ATP-binding proteins. Microbiology 143, 1389-1394
1996
J. Król, M. Janczarek, A. Wojcieszuk, A. Skorupska, 1996. The clover (Trifolium sp.) and Rhizobium leguminosarum bv. trifolii symbiosis: a system for study the significance of acidic polysaccharides. Bull. Polish Academy of Science, 44, 1-5.
1995
Skorupska A., J. Król, 1995. Extracellular polysaccharides in Rhizobium: their role in symbiosis with clover plants. Kosmos, 44, (3/4), 589-600.
Skorupska A., J. Król, 1995. Nodulation response of exopolysaccharide deficient mutants of Rhizobium leguminosarum bv. trifolii to addition of acidic polysaccharide. Microbiol. Res. 150; 297-303.
Conference Papers – selected
2006
Król J.E., Mazur A., Marczak M., Bigoraj E, Skorupska A. 2006. Construction of the physical map of Rhizobium leguminosarum bv. trifolii TA1 genome. II Konferencja Komitetu Mikrobiologii PAN, Lublin 2006. Materialy Zjazdowe, str. 53.
Król J.E., Mazur A., Marczak M., Kepka M, Skorupska A. 2006. Identification and in silico analysis of Rhizobium leguminosarum bv. trifolii TA1 polysaccharide biosynthesis regions. II Konferencja Komitetu Mikrobiologii PAN, Lublin 2006. Materialy Zjazdowe, str. 54.
Marczak M., Mazur A., Król J., Skorupska A. 2006. Secondary structure and topolygy of PssN lipoprotein nenber of the exopolysaccharide transport system in Rhizobium leguminosarum bv. trifolii TA1. II Konferencja Komitetu Mikrobiologii PAN, Lublin 2006. Materialy Zjazdowe, str. 59.
Mazur A., Król J., Marczak M., Górniak A., Skorupska A. 2006. Identification and in silico analysis of Rhizobium leguminosarum bv. trifolii TA1 polysaccharide biosynthesis plasmid region. II Konferencja Komitetu Mikrobiologii PAN, Lublin 2006. Materialy Zjazdowe, str. 60.
Chudnicka A., Król J., Walory J., Koziol-Montewka M. 2006. Characteristic of nontoxic strain of Corynebacterium dipphteriae isolated from blood. II Konferencja Komitetu Mikrobiologii PAN, Lublin 2006. Materialy Zjazdowe, str. 39.
Turska-Szewczuk A., Kutkowska J., Król J., Urbanik-Sypniewska T., Dolecka J., Pietras H., Koltun J., Russa R. 2006. Altered distribution of lipopolysaccharide O-antigenic chain of Mesorhizobium loti NZP2213.1 prevents the establishment of effective symbiosis with Lotus corniculatus. II Konferencja Komitetu Mikrobiologii PAN, Lublin 2006. Materialy Zjazdowe, str. 60.
Król J.E., Mazur A., Marczak M. and Skorupska A. 2006. Physical and genetic map of the Rhizobium leguminosarum bv. trifolii TA1 genome. 7th European Nitrogen Fixation Conference, Aarhus (Denmark). p. 50.
Marczak M., Mazur A., Król J., Gruszecki W., Skorupska A. 2006. Secondary structure and topology of PssN lipoprotein, a component of exopolysaccharide transport system in Rhizobium leguminosarum bv. trifolii TA1. 7th European Nitrogen Fixation Conference, Aarhus (Denmark). p. 51.
Mazur A., Król J., Marczak M., Skorupska A. 2006. In silico analysis of polysaccharide biosynthesis clusters in Rhizobium leguminosarum bv. trifolii TA1. 7th European Nitrogen Fixation Conference, Aarhus (Denmark). p. 52.
Król J.E., Mazur A., Marczak M. and Skorupska A. 2006. A genomic approach to analyse polysaccharide biosynthesis genes in Rhizobium leguminosarum bv. trifolii. 7th European Nitrogen Fixation Conference, Satellite meeting on Genomics of Nitrogen-Fixing Organisms, Aarhus (Denmark). p. 178.
2005
Król J.E., Mazur A., Marczak M. and Skorupska A. 2005. Mapping of the Rhizobium leguminosarum bv. trifolii TA1 genome. The First Baltic Sea Region Symposium and Postgraduate course "Agro-biotechnology focused on root-microbe systems", Kowno (Litwa). Materialy Zjazdowe, str. 33-34.
Król J.E., Mazur A., Marczak M. and Skorupska A. (2005) Mapping of the Rhizobium leguminosarum bv. trifolii TA1 genome. 40th Meeting of The Polish Biochemical Society, Lublin 2005. Materialy Zjazdowe, str. 9.
2004
Mazur A., Marczak M., Król J., Skorupska A. 2004. Topological and functional analysis of PssL protein, putative exopolysaccharide transporter in Rhizobium leguminosarum bv. trifolii TA1. Proceedings of the Sixth European Nitrogen Fixation Conference, Toulouse (Francja), nr sekcji P3.15, str. 40.
Król J., Mazur A., Marczak M., Rybak A., Komisarczuk A., Skorupska A. 2004. Identification of exopolysaccharide biosynthesis region in Rhizobium leguminosarum bv. trifolii BAC library. Proceedings of the Sixth European Nitrogen Fixation Conference, Toulouse (Francja), nr sekcji P3.23, str. 44.
2003
Mazur A., Marczak M., Król J., Skorupska A. 2003. Using the gene fusions in topology studies of Rhizobium leguminosarum bv. trifolii exopolysaccharide membrane transporters. Materialy II Krajowego Kongresu Biotechnologii, Lódz, str. 230.
2002
Schulmeister S. A., Król J., Vorhoelter F., Skorupska A., Lotz W. 2002. Sequence analysis of the Sinorhizobium meliloti 2011 temperate bacteriophage PBC5. Fifth European Nitrogen Fixation Conference, Norwich, UK.
Mazur A., Król J., Marczak M., Skorupska A. 2002. Membrane topology of the Rhizobium leguminosarum bv. trifolii TA1 PssT protein. Fifth European Nitrogen Fixation Conference, Norwich, UK. No.3.10
Król J., Mazur A., Olech B., Skorupska A. 2002. Identification and analysis of the pssT gene of Rhizobium leguminosarum bv. trifolii TA1. Fifth European Nitrogen Fixation Conference, Norwich, UK. No. 4.5
2001
Mazur A., Król J. Skorupska A. 2001. Function of the PssP protein in exopolysaccharide biosynthesis in Rhizobium leguminosarum bv. trifolii TA1 Materialy XIV Zjazdu P.T. Genet., Poznan, str. 88.
2000
Mazur A., Król J., Skorupska A. 2000. Exopysaccharide as the model molecular mediator in plant stress responce to the rhizobial infection. Konferencja "Stres w badaniach biologicznych i medycznych", Lublin, 122.
Mazur A., Lejman M., Król J., Skorupska A. 2000. The pssNOP region of Rhizobium leguminosarum bv. trifolii transcriptional activity. The Fourth European Nitrogen Fixation Conference, Sevilla, Hiszpania, str. 198.
1999
Mazur, A., Król, J., Skorupska, A. 1999. Functional analysis of pssNOP genes, involved in exopolysaccharide production in Rhizobium leguminosarum bv. trifolii TA1. I Krajowy Kongres Biotechnologii, Wroclaw, p.16.
Król, J., Skorupska, A. 1999. Homology of the genes involved in exopolysaccharide biosynthesis and modification in selected plant symbionts and pathogens. I Krajowy Kongres Biotechnologii, Wroclaw, p. 149.
1998
Kopcinska J., Lotocka B., Skorupska A., Król J. 1998. Disturbances in infection thread development in nodules induced by the exo- mutants in clover Mat. 51 Zjazdu PTBotan., Gdansk, str. 229.
Mazur A., Wielbo J., Król J., Skorupska A. 1998. Molecular characterization and symbiotic importance of prsD gene Rhizobium leguminosarum bv. trifolii TA1. J. Appl. Genet. 39.A, 171.
Król J., Mazur A., Wielbo J., Janczarek M., Skorupska A. 1998. Genetic organization of the exo region Rhizobium leguminosarum: identification of pssNOP genes. J. Appl. Genet. 39A, 173.
Janczarek M., Król J., Skorupska A. 1998. The pssB gene product of Rhizobium leguminosarum bv. trifolii is homologous to a family of inositol monophosphatases. J. Appl. Genet. 39A, 173.
Król, J., Mazur, A., Wielbo, J., Janczarek, M., Skorupska, A. 1998. Identification of the pssNOP genes of Rhizobium leguminosarum bv. trifolii. Third European Nitrogen Fixation Conference, Lunteren, Holandia, p.97.
1997
Król J., Mazur A., Sawicki R., Wielbo J., Skorupska A. 1997. ABC type protein transport system in Rhizobium leguminosarum bv. trifolii; functional relationschipo to other Gram negative bacteria. Mat. XXXIII Zjazdu PTBioch., Katowice, str. 25
1996
Janczarek M., Król J., Skorupska A. 1996. Searching for the new DNA regions controlling exopolysaccharide synthesis in Rhizobium leguminosarum bv. trifolii. Materialy XXIII Zjazdu PTM, Lódz, s.85.
Król J., Janczarek M., Skorupska A. 1996. Identification of the genes in Rhizobium leguminosarum bv. trifolii whose products are homologues to a family of ATP binding proteins. 2 nd European Nitrogen Fixation Conference & NATO Advanced Research Workshop "Biological Fixation of Nitrogen for Ecology and Sustainable Agriculture", Poznan, s.126.
1995
Król J., Skorupska A. 1995.Homology between exo region of Rhizobium leguminosarum bv. trifolii and genes controlling synthesis and export of alkaline protease in Pseudomonas aeruginosa and Erwinia chrysanthemi. Materialy XXXI Zjazdu PTBioch. W-wa, 118A.
Król J., Marek-Kozaczuk M., Skorupska A. 1995. Mutational analysis of DNA region controlling exopolysaccheride synthesis in Rhizobium leguminosarum bv. trifolii. J. Appl. Genet. vol. 36A, 34.
Marek-Kozaczuk M., Król J. Skorupska A. 1995. Tn5 mutants of Pseudomonas sp. 267 defective in siderophore synthesis. J. Appl. Genet. vol. 36A, 34.
Skorupska A, Derylo M., Król J., Marek-Kozaczuk M. 1996. Genetic and sequencing analysis of DNA region involved in synthesis of exopolysaccharide in Rhizobium leguminosarum bv. trifolii Materialy z Konferencja Sprawozdawczej Programu BiMol FNP, Gdansk ,34.
1994
Król J., Wojcieszuk A., Skorupska A. 1994. Cloning and sequencing exo region from Rhizobium leguminosarum bv. trifolii. Proc. 1-st European Nitrogen Fixation Conference, Szeged, Officina Press, p.319
…Education
- 1999 Doctor degree in biological sciences: Ph.D. thesis: " Genetic and sequencing analysis of DNA region involved in synthesis of exopolysaccharide in Rhizobium leguminosarum bv. trifolii". Supervisor: dr hab. Anna Skorupska, prof. UMCS
- 1993 Master of Science in Biotechnology, Department of General Microbiology, Maria-Curie Sklodowska University
…Professional Experience
- 2007 - present University of Idaho, Department of Biological Sciences - postdoctoral position
- 2003 - 2007 Maria Curie-Sklodowska University Lublin, Head of the Faculty Computer Unit
- 1999 - 2007 Maria Curie-Sklodowska University Lublin, Department of General Microbiology - postdoctoral position
- 1999 FEMS Fellowship - Institute Pasteur - Paris, (2 months)
- 1993 - 1999 Teaching and Research Assistant at Department of General Microbiology, Universtiy of Maria Curie-Sklodowska
- 1992 National Veterinary Research Institute in Pulawy, Summer Practice, 1 month
…Courses
The First Baltic Sea Region Symposium and Postgraduate course “Agro-biotechnology focused on root-microbe systems”, Kaunas (Lithuania) 2 weeks, 2005 (Teacher)
Institute of Biochemistry and Biophisics Polish Academy of Science Warsaw, “DNA sequencing and sequence analyses” practical course, 1 week, 2003
Centre of Excellence in Molecular Biotechnology, Institute of Biochemistry and Biophisics Polish Academy of Science Warsaw “Advanced Theoretical Course on Signals Involved in Plant-Microbe Interactions”, Goniadz 2002
International Center for Genetic Engineering and Biotechnology (ICGEB), “Practical Course – Computer methods in molecular biology” Italy, 2 weeks, 1999
International Center for Genetic Engineering and Biotechnology (ICGEB), 10th Anniversary Symposium “Molecular Biology and Biotechnology for Development” Italy, 1 week, 1997
Institute of Bioorganic Chemistry Polish Academy of Science Poznan, “Molecular probes in molecular biology”, practical course, 1 week, 1993
…Educational Courses at University
Genetics – Mendelian Genetics, genome organization, construction of genetic and physical maps, genetic control of transcription and replication in Eucaryota and Procaryota, mutagenesis and reparation systems, restriction and modification, transformation, transduction and conjugation
Plant Biotechnology – purpose of plant biotechnology, plant genomics, use of genetic engineering methods for plant transgenesis, plant transformation methods and vector construction, reporter genes, antisense and RNAi technology
Genetic Engineering – molecular cloning and enzymes used in these methods, vectors construction and characterization, transformation and selection methods, DNA and cDNA library construction, PCR techniques, electrophoresis, Southern, Northern and Western hybridization, DNA sequencing and genome analyses, mutagenesis, DNA micro – and macroarrays
Bioinformatics – DNA sequence analyses (restriction analyses, ORF and regulatory sequences findings, contig formation, searching for repeated sequences, in silico translation), molecular data bases (GenBank, EMBL, DDJB, PIR, SwissProt), searching for information (Entrez, SRS), homology searching (Blast, FASTA, Blitz), DNA sequence submission and so on.
…Organized Courses
Institute of Microbiology and Biotechnology University of Maria Curie-Sklodowska Lublin. “Use of PCR methods in molecular diagnostic”, Practical course, 1 week, 2003
Voivodship Sanitary and Epidemiological Station in Warsaw. “Use of PCR methods in molecular diagnostic”, Practical course, 1 week, 2003
Commission of Biotechnology Polish Academy of Science Lublin Branch - Pulawy “Basics of Bioinformatics” Practical course, 1 week, 2004
Center of Biotechnology University of Maria Curie-Sklodowska Lublin “Basics of Bioinformatics” Practical course, 1 week, 2005
Center of Biotechnology University of Maria Curie-Sklodowska Lublin “Basics of Bioinformatics” Practical course, 1 week, 2005
…Honors and Awards
1st Award of Memory of Prof. Kazimierz Bassalik from Committee of Microbiology, Polish Academy of Science – 2007
2nd Award of Memory of Prof. Kazimierz Bassalik from Committee of Microbiology, Polish Academy of Science – 2004
1st Team Award of Organization Committee of The First National Biotechnology Congress, Lódz 2003
(For original papers in 2001 – 2003)
2nd Team Award of Polish Genetic Society, Poznan 2001, (For original papers in 1999 – 2001)
Award of Ministry of Education – 1999, (for the best PhD thesis)
Scholarship for Young Scientists from Foundation for Polish Science – 1999
2nd Team Award of J.M. Rector University of Maria Curie-Sklodowska –1998
Letter of Congratulations of J.M. 2nd Team Award of J.M. Rector University of Maria Curie-Sklodowska – 1996
Rector of University of Maria Curie-Sklodowska – MS with honors – 1993
…Memberships and Affiliations
Polish Genetic Society
Polish Society of Microbiologists
Microbiology Committee of The Polish Academy of Sciences (1999 – 2003)
Biotechnology Commission Polish Academy of Sciences Lublin Branch (Secretary)(2003 – present)
Faculty of Biology and Earth Sciences Board (1999 – 2005)
Scholarship for Young Scientists from Foundation for Polish Science – 1999
Institute of Microbiology and Biotechnology Board (2006 – present)
...Research specific skills
- Construction and screening of DNA Library (Plasmid's, Cosmid's and BAC's)
- BAC contigs construction
- PCR amplification and cloning of bacterial specific genes
- DNA sequencing and sequence analysis (large fragments sequencing – primer walking, subcloning, nested deletions, transposon flanks sequencing)
- Mutagenesis of random and specific genes
- Microbe identification
- Protein overexpression and purification (bacterial systems using His-Tagged and Mal-Tagged proteins)
- Use of reporter genes (lacZ and phoA) to study topology of membrane proteins (gene fusions)
- Use of reporter genes (gusA and gfp) for microbe labeling and detection
- Enzyme kinetics and activity
- Bacterial polysaccharides extraction, purification and analysis
- Human genes SNP analyses
…Laboratory Skills
- RNA/DNA extraction from tissues and bacterial sources
- Restriction enzymes analyses and mapping
- DNA electrophoresis – agarose and polyacrylamide gels, standard and PFGE electrophoresis (FIGE and CHEF–CHEF DRIII system from BioRad)
- DNA cloning
- Bacterial transformation (chemical and electrotransformation) and conjugation
- DNA sequencing – manual (32Pand 35S labeled), automatic with ALF (Pharmacia LKB) and ABI 310 (Applera)
- Southern, Northern and Western Blotting
- Dot, Slot blot, colony hybridization, radiolabelled and DIG probes preparation
- PCR and RT–PCR skills (RAPD, AFLP, PCR-RFLP, PCR-SSCP, PCR sequencing)
- PCR and RT–PCR skills (RAPD, AFLP, PCR-RFLP, PCR-SSCP, PCR sequencing)
- Primer and probes design for cloning and diagnostic PCR, sequencing and hybridization
- Gene fusion construction and reporter genes analyses
- Protein Purification (affinity, ion exchange chromatography)
- Preparation of recombinant proteins for antibody production
