Linda Rogers, Scientific Aide
…Research
I am involved in the research on horizontal transfer of genetic information via broad-host-range (BHR) plasmids. These mobile genetic elements are important in that they facilitate the inter-species transfer of genes that allow bacteria to live in the presence of environmental stresses such as heavy metals, chlorinated hydrocarbons, and antibiotics.
One part of the research aims at understanding the diversity and evolutionary history of BHR plasmids. This work entails capturing novel BHR plasmids from the environment (industrial, agricultural and hospital sites, waste water treatment facilities), and extracting large amounts of high-quality plasmid DNA. These new plasmids will be sequenced in conjunction with the Joint Genome Institute, and the sequences will be functionally annotated and compared to already known BHR plasmids. More information on the genome sequences of these important mobile elements will not only improve our insight in their diversity and evolutionary history, but it will also allow us to better use their ‘valuable’ traits, such as in bioremediation, and to counter their ‘detrimental’ traits, such as antibiotic resistance.
The second part of the research studies the effects of spatial structure on plasmid transfer and persistence in bacterial populations. Our main question here is: Can plasmids persist in, or even invade, bacterial populations in the absence of selection, and how? I am working with Dr. Haruo Suzuki and Randal Fox on their experiments addressing the effects of spatial structure on plasmid spread on agar plates and in biofilms.
…Publications
2007
Niu, J., Azfer, A., Rogers, L. M., Wang, X. and Kolattukudy, P. E. (2007) Cardioprotective effects of cerium oxide nanoparticles in a transgenic murine model of cardiomyopathy. Cardiovasc. Res. 73: 549-559.
2006
Azfer, A., Niu, J., Rogers, L. M., Adamski, F. M. and Kolattukudy, P. E. (2006) Activation of endoplasmic reticulum stress response during the development of ischemic heart disease. Am. J. Physiol. Heart Circ. Physiol. 291: H1411-20. Epub 2006 Apr 14.
2005
Yang, Z., Rogers, L. M., Song, Y., Guo, W. and Kolattukudy, P. E. (2005) Homoserine and asparagine are host signals that trigger in planta expression of a pathogenesis gene in Nectria haematococca. Proc. Natl. Acad. Sci. USA 15: 4197-4202. Epub 7 March, 2005.
2002
Li, D., Sirakova, T., Rogers, L., Ettinger, W.F. and Kolattukudy, P.E. (2002) Regulation of constitutively expressed and induced cutinase genes by different zinc finger transcription factors in Fusarium solani f pisi (Nectria haematococca). J. Biol. Chem. 277: 7905-7912.
2000
Kolattukudy, P.E., Kim, Y., Li, D., Liu, Z.M. and Rogers, L. (2000) Early molecular communication between Colletotrichum gloeosporioides and its host. In: Host Specificity, Pathology and Host Pathogen Interaction of Colletotrichum (Dickman, M., Freeman, S. and Prusky, D., eds.), The American phytopathological Society, St.Paul, MN. pp. 78-98.
Rogers, L., Kim, Y., Guo, W., González-Candelas, L., Li, D. and Kolattukudy, P.E. (2000) Requirement for either a host-induced or a pectin-induced pectate lyase for infection of Pisum sativum by Nectria haematococca. Proc. Natl. Acad. Sci. USA 97: 9813-9818.
1998
Chakravarty, L., Rogers, L., Quach, T. Breckenridge, S. and Kolattukudy, P.E. (1998) Lysine 58 and histidine 66 at the C-terminal α helix of the monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding. J. Biol. Chem. 273: 29641-29647.
1997
Li, D., Rogers, L. and Kolattukudy, P.E. (1997) Cloning and expression of cDNA encoding a mitogen-activated protein kinase from a phytopathogenic filamentous fungi. Gene 195: 161-166.
1996
Azad, A.K., Sirakova, T.D., Rogers, L.M. and Kolattukudy, P.E. (1996) Targeted replacement of the mycocerosic acid synthase gene in Mycobacterium bovis BCG produces a mutant that lacks mycosides. Proc. Natl. Acad. Sci. USA 93: 4787-4792.
1995
Kolattukudy, P.E, Rogers, L.M., Li, D., Hwang, C.-S. and Flaishman, M.A. (1995) Surface signaling in pathogenesis. Proc. Natl. Acad. Sci. USA 92: 4080-4087.
1994
Rogers, L.M., Flaishman, M.A. and Kolattukudy, P.E. (1994) Cutinase gene disruption in Fusarium solani f. sp. pisi decreases its virulence on pea. Plant Cell 6: 935-945.
Kämper, J., Kämper, U., Rogers, L.M. and Kolattukudy, P.E. (1994) Identification of regulatory elements in the cutinase promoter from Fusarium solani f. sp. pisi (Nectria haematococca). J. Biol. Chem. 269: 9195-9204.
1993
Podila, G.K., Rogers, L.M. and Kolattukudy, P.E. (1993) Chemical signals from avocado surface wax trigger germination and appressorium formation in Colletotrichum gloeosporioides. Plant Physiol. 103: 267-272.
Kolattukudy, P.E., Lee, J.D., Rogers, L.M., Zimmerman, P., Ceselski, S., Fox, B., Stein, J.B. and Copelan, E. (1993) Evidence for possible involvement of an elastolytic serine protease in Aspergillosis. Infect. Immun. 61: 2357-2368.
1991
Kolattukudy, P.E., Bohnet, S., Sasaki, G. and Rogers, L. (1991) Developmental changes in the expression of S-acyl fatty acid synthase thioesterase gene and lipid composition in the uropygial gland of mallard ducks (Anas platyrhynchous). Arch. Biochem. Biophys. 284: 201-206.
Bohnet, S., Rogers, L., Sasaki, G. and Kolattukudy, P.E. (1991) Estradiol induces peroxisome proliferation and the production of 3-hydroxy fatty acid diesters, the female pheromones, in the uropygial glands of male and female mallards. J. Biol. Chem. 266: 9795-9804.
1989
Podila, G.K., Dickman, M.B., Rogers, L.M. and Kolattukudy, P.E. (1989) Regulation of expression of fungal genes by plant signals, in Molecular Biology of Filamentous Fungi, (H. Nevalainen and M. Penttilä, eds.), Foundation for Biotechnical and Industrial Fermentation Research 6: 217-226.
1987
Kolattukudy, P.E. and Rogers, L.M. (1987) Biosynthesis of 3-hydroxy fatty acids, the pheromone components of female mallard ducks, by cell-free preparation from the uropygial gland. Arch. Biochem. Biophys. 252: 121-129.
Kolattukudy, P.E., Rogers, L.M., Poulose, A.J., Jang, S.H., Kim, Y.S., Cheesbrough, T.M. and Liggitt, D.H. (1987) Developmental pattern of the expression of malonyl-CoA decarboxylase gene and the production of unique lipids in the goose uropygial glands. Arch. Biochem. Biophys. 256: 446-454.
Kolattukudy, P.E., Bohnet, S. and Rogers, L.M. (1987) Diesters of 3-hydroxy fatty acids produced by the uropygial glands of female mallards uniquely during the mating season. J. Lipid Res. 28: 582-588.
Kolattukudy, P.E., Rogers, L.M. and Balapangu, A. (1987) Synthesis of methyl-branched fatty acids from methylmalonyl-CoA by fatty acid synthase from both the liver and the Harderian gland of the guinea pig. Arch. Biochem. Biophys. 255: 205-209.
Kolattukudy, P.E., Bohnet, S., Roberts, E. and Rogers, L. (1987) Peroxisomes in sebaceous glands: biosynthetic role and hormonal regulation, in Peroxisomes in Biology and Medicine (H.D. Fahimi and H. Sies, eds.), Springer-Verlag, Berlin, 18-31.
1986
Kolattukudy, P.E. and Rogers, L.M. (1986) Acyl-CoA reductase and acyl-CoA fatty alcohol acyl transferase in the microsomal preparation from the bovine meibomian gland. J. Lipid Res. 27: 404-411.
1985
Kolattukudy, P.E., Rogers, L. and Flurkey, W. (1985) Supression of a thioesterase gene expression and the disappearance of short chain fatty acids in the preen gland of the mallard duck during eclipse, the period following post-nuptial molt. J. Biol. Chem. 260: 10789-10793.
Kolattukudy, P.E., Bohnet, S. and Rogers, L. (1985) Disappearance of short chain acids from the preen gland wax of mallard ducks during eclipse. J. Lipid Res. 26:989-994.
Kolattukudy, P.E., Rogers, L.M. and Nicolaides, N. (1985) Biosynthesis of lipids by bovine meibomian glands. Lipids 20: 468-474.
Poulose, A.J., Rogers, L., Cheesbrough, T.M. and Kolattukudy, P.E. (1985) Cloning and sequencing of the cDNA for S-acyl fatty acid synthase thioester hydrolase from the uropygial gland of mallard duck. J. Biol. Chem. 260: 15953-15958.
1984
Bognar, A.L., Paliyath, G., Rogers, L. and Kolattukudy, P.E. (1984) Biosynthesis of alkanes by particulate and solubilized preparation from pea leaves (Pisum sativum). Arch. Biochem. Biophys. 235: 8-17.
Rogers, L. and Kolattukudy, P.E. (1984) Purification of S-acyl fatty acid synthase thioester hydrolase by affinity chromatography with fatty acid synthase attached to Sepharose. Anal. Biochem. 137: 444-448.
1982
Rogers, L., Kolattukudy, P.E. and deRenobales, M. (1982) Purification and characterization of an S-acyl fatty acid synthase thioester hydrolase which modifies the product specificity of fatty acid synthase in the uropygial gland of mallard. J. Biol. Chem. 257: 880-886.
1981
Kolattukudy, P.E., Bedord, C.J. and Rogers, L. (1981) Thioesterase segment from the fatty acid synthase of the uropygial gland of goose, in Methods in Enzymology, Vol. 71 (J.M. Lowenstein, ed.), Academic Press, New York, 230-234.
Kolattukudy, P.E., Rogers, L. and Larson, J.D. (1981) Enzymatic reduction of fatty acids and α-hydroxyfatty acids, in Methods in Enzymology, Vol. 71 (J.M. Lowenstein, ed.), Academic Press, New York, 263-275.
Poulose, A.J., Rogers, L. and Kolattukudy, P.E. (1981) Primary structure of a chymotryptic peptide containing the “active serine” of the thioesterase domain of fatty acid synthase. Biochem. Biophys. Res. Commun. 103: 377-382.
1980
Poulose, A.J., Rogers, L. and Kolattukudy, P.E. (1980) Selective chemical modification of the active sites of the ketoacyl reductase and enoyl reductase of fatty acid synthetase from lactating rat mammary glands. Int. J. Biochem. 12: 591-596.
deRenobales, M., Rogers, L. and Kolattukudy, P.E. (1980) Involvement of a thioesterase in the production of short-chain fatty acids in the uropygial glands of mallard ducks (Anas platyrhynchous). Arch. Biochem. Biophys. 205: 464-477.
Work cited under the name Linda M. Brown
1978
Bedord, C.J., Kolattukudy, P.E. and Brown, L. (1978) Isolation and characterization of a tryptic fragment containing the thioesterase` segment of fatty acid synthetase from the uropygial gland of goose. Arch. Biochem. Biophys. 186:139-151.
Buckner, J.S., Kolattukudy, P.E. and Brown, L. (1978) Synthesis of multimethyl-branched acids by avian and mammalian fatty acid synthetase and its regulation by malonyl-CoA decarboxylase in the uropygial gland. Arch. Biochem. Biophys. 186:152-162.
Kolattukudy, P.E. and Rogers, L. (1978) Biosynthesis of fatty alcohols, alkane-1,2-diols, and wax esters in particulate preparations from the uropygial glands of white-crowned sparrows (Zonotrichia leucophrys). Arch. Biochem. Biophys. 191: 244-258.
Kolattukudy, P.E., Riley, R.G. and Rogers, L. (1978) Biosynthesis of alkane-2,3-diols: enzymatic reduction of 3-hydroxyoctadecane-2-one to octadecane-2,3-diol by a NADPH (B-side) specific microsomal reductase from the uropygial glands of ring-necked pheasants (Phasianus colchicus). Arch. Biochem. Biophys. 189: 433-440.
1975
Kolattukudy, P.E. and Brown, L. (1975) Fate of naturally occurring epoxy acids: a soluble epoxide hydrase, which catalyzes cis hydration, from Fusarium solani pisi. Arch. Biochem. Biophys. 166: 599-607.
1974
Kolattukudy, P.E. and Brown, L. (1974) Inhibition of cuticular lipid biosynthesis in Pisum sativum by thiocarbamates. Plant Physiol. 53: 903-906.
Kolattukudy, P.E., Croteau, R. and Brown, L. (1974) Structure and biosynthesis of cuticular lipids: hydroxylation of palmitic acid and decarboxylation of C28, C30 and C32 acids in Vicia faba flowers. Plant Physiol. 54: 670-677.
1972
Kolattukudy, P.E., Buckner, J.S. and Brown, L. (1972) Direct evidence for a decarboxylation mechanism in the biosynthesis of alkanes in B. oleracea. Biochem. Biophys. Res. Commun. 47: 1306-1313.
Not cited are acknowledgments for technical assistance in (forty-seven) papers, assistance in manuscript preparation in (seven) papers, and both technical assistance and manuscript preparation in (two) review chapters.